The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now wit
Cell Cycle Control
β Scribed by R. J. Sheaff, J. M. Roberts (auth.), Dr. Michele Pagano (eds.)
- Publisher
- Springer-Verlag Berlin Heidelberg
- Year
- 1998
- Tongue
- English
- Leaves
- 237
- Series
- Results and Problems in Cell Differentiation 22
- Edition
- 1
- Category
- Library
No coin nor oath required. For personal study only.
β¦ Synopsis
Leafing through a journal of biology will almost certainly turn up several artiΒ cles on some aspect of the eukaryotic cell division cycle. The progress in unΒ derstanding the modus operandi of the cell cycle machinery and its central role in controlling cell proliferation has awakened a great deal of interest in many biologists. However, the cell cycle field often seems unnecessarily complicated, perhaps because data are acquired in bits and pieces and almost all simultaneΒ ously from studies using different systems and organisms. The aim of this book is to make the background of the cell cycle field as unambiguous and clear as possible by distinguishing what is commonly accepted in the field from what are the unsolved problems. Therefore, this book is intended to serve a large auΒ dience: graduate and postgraduate students, basic and clinical scientists inΒ volved in the study of cell growth, differentiation, senescence, apoptosis, and cancer. My hope is that this book will stimulate further interest in the fascinatΒ ing field of the cell cycle and help scientists find connections between this and their fields of interest. This book brings together experts to review all major aspects of the eukaryΒ otic cell division cycle. The cell cycle is a coordinated and highly regulated series of events during which the cell replicates its DNA, and then divides.
β¦ Table of Contents
Front Matter....Pages I-XI
Regulation of G1 Phase....Pages 1-34
Regulation of S Phase....Pages 35-55
Regulation of the G2 to M Transition....Pages 57-78
Regulation of CDKs by phosphorylation....Pages 79-109
Regulation of the cell cycle by CDK inhibitors....Pages 111-131
Regulation of the Cell Cycle by the Ubiquitin Pathway....Pages 133-147
Regulation of the Cell Cycle by the Rb Tumor Suppressor Family....Pages 149-179
Control of Cell Proliferation by Myc Proteins....Pages 181-197
Growth Regulation by the E2F and DP Transcription Factor Families....Pages 199-227
Back Matter....Pages 229-232
β¦ Subjects
Cell Biology; Biochemistry, general; Cancer Research
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