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Cell Cycle Checkpoints and DNA Repair in Nijmegen Breakage Syndrome

✍ Scribed by Kathleen E. Sullivan; Ekaterina Veksler; Howard Lederman; Susan P. Lees-Miller

Book ID
112240921
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
181 KB
Volume
82
Category
Article
ISSN
1090-2341

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Nijmegen breakage syndrome: consequences
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✍ Martin Digweed; AndrΓ© Reis; Karl Sperling πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 85 KB

The autosomal recessive genetic disorder, Nijmegen Breakage Syndrome, is characterised by an excessively high risk for the development of lymphatic tumours and an extreme sensitivity towards ionising radiation. The most likely explanation for these characteristics, a deficiency in the repair of DNA