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Cell cycle arrest is sufficient for p53-mediated tumor regression

โœ Scribed by Dubrez, L; Coll, J-L; Hurbin, A; de Fraipont, F; Lantejoul, S; Favrot, M-C


Book ID
110039037
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
257 KB
Volume
8
Category
Article
ISSN
0969-7128

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## Abstract The major longโ€term prognostic factor for breast cancer patients treated by firstโ€line chemotherapy is response to treatment. We have previously shown that complete responses to high doses epirubicinโ€cyclophosphamide were observed only in human tumors bearing a __TP53__ mutation. Three