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Cell culture media supplementation of uncommonly used sugars sucrose and tagatose for the targeted shifting of protein glycosylation profiles of recombinant protein therapeutics

✍ Scribed by Hossler, Patrick; McDermott, Sean; Racicot, Christopher; Chumsae, Christopher; Raharimampionona, Haly; Zhou, Yu; Ouellette, David; Matuck, Joseph; Correia, Ivan; Fann, John; Li, Jianmin

Book ID: 127024547
Publisher: American Institute of Chemical Engineers
Year: 2014
Tongue: English
Weight: 785 KB
Volume: 30
Category: Article
ISSN: 8756-7938
DOI: 10.1002/btpr.1968

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## Abstract Soy peptones or soy hydrolysates are widely used as key medium additives in serum‐free cell culture processes for industrial production of therapeutic recombinant proteins. The heterogeneous nature of these vegetable‐derived materials can lead to substantial lot‐ to‐lot variability in c