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Cell coupling regulates Ins1, Pdx-1 and MafA to promote insulin secretion in mouse pancreatic beta cells

✍ Scribed by Kai-Chiang Yang; Zhi Qi; Goichi Yanai; Yasumasa Shirouza; Dai-Hua Lu; Hsuan-Shu Lee; Shoichiro Sumi


Book ID
113862858
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
516 KB
Volume
46
Category
Article
ISSN
1873-3298

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## Abstract Impairment of glucose‐stimulated insulin secretion (GSIS) caused by glucolipotoxicity is an essential feature in type 2 diabetes mellitus (T2DM). Palmitate and eicosapentaenoate (EPA), because of their lipotoxicity and protection effect, were found to impair or restore the GSIS in beta