β Scribed by Marco A. Zarbin, Mandeep S. Singh, Ricardo P. Casaroli-Marano
No coin nor oath required. For personal study only.
This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of βde-riskingβ that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.
Front Matter ....Pages i-xi
Advantages of the Eye as a Target Organ for Cell-Based Therapy in the Central Nervous System (Marco A. Zarbin)....Pages 1-10
Proof of Principle: Preclinical Data on Retinal Cell Transplantation (Karl A. Z. Hudspith, Gibert Xue, Mandeep S. Singh)....Pages 11-28
Clinical and Pathological Features of Selected Human Retinal Degenerative Diseases (Michael C. Hogden, Stephen Tsang)....Pages 29-51
Degenerative Retinal Diseases: Cell Sources for Cell-Based Therapy (Ricardo P. Casaroli-Marano, NΓΊria Nieto-Nicolau, Raquel A. MartΓnez-GarcΓa de la Torre)....Pages 53-80
Manufacturing of Clinical Grade Cellular Products Under GMP Conditions (Brian Fury, Henry Klassen, Gerhard Bauer)....Pages 81-95
Regulatory Requirements for Cell-Based Therapy for Degenerative Retinal Disease (Gary D. Novack)....Pages 97-107
Biomaterials and Scaffolds for Cell Replacement Therapy (Marta Stevanovic, Debbie Mitra, Dennis O. Clegg, Mark S. Humayun)....Pages 109-140
Transplantation Immunology: Retinal Cell-Based Therapy (Harpal Sandhu, Janelle M. F. Adeniran, Henry J. Kaplan)....Pages 141-156
Restoration of Cone Photoreceptor Function in Retinitis Pigmentosa (RP): Retinal Cell-Based Therapy (Henry J. Kaplan, Wei Wang, Douglas C. Dean)....Pages 157-166
Cell Delivery: Surgical Approaches (Odysseas Georgiadis, Peter J. Coffey, Lyndon da Cruz)....Pages 167-192
Diagnosis and Complementary Examinations (Young Ju Lew, Jacque L. Duncan)....Pages 193-216
Cell Therapy for Degenerative Retinal Disease: Special Focus on Cell Fusion-Mediated Regeneration (Francesco Sottile, Martina Pesaresi, Giacoma Simonte, Maria Pia Cosma)....Pages 217-244
Clinical Trials of Retinal Cell Therapy (Kanza Aziz, Marco A. Zarbin, Mandeep S. Singh)....Pages 245-265
Future Directions (Mandeep S. Singh, Marco A. Zarbin)....Pages 267-271
Back Matter ....Pages 273-280
Life Sciences; Stem Cells; Regenerative Medicine/Tissue Engineering; Ophthalmology
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