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Cell-associated and soluble phospholipases A2 increase during carrageenan and zymosan-induced pleurisy in rat

✍ Scribed by Tesson, Frédérique; Ruffié, Claude; Hidi, Rabia; e Silva, Patricia M.R.; Vazeux, Gilles; Vargaftig, B.Boris; Bon, Cassian


Book ID
122359713
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
509 KB
Volume
248
Category
Article
ISSN
0926-6917

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## Abstract Secreted phospholipases A~2~ (sPLA~2~s) modulate neuronal survival and neurotransmitter release. Here we show that sPLA~2~ (group III) synergistically increases glutamate‐induced cell death and intracellular calcium ([Ca^2+^]~i~) in cultured primary cortical and hippocampal neurons. Whe