## Abstract Binding of typeβ1 plasminogen activator inhibitor (PAIβ1) to cell surface urokinase (uPA) promotes inactivation and internalization of adhesion receptors (e.g., urokinase receptor (uPAR), integrins) and leads to cell detachment from a variety of extracellular matrices. In this report, w
Cell Adhesion Regulates the Plasminogen Activator Inhibitor-1 Gene Expression in Anchorage-Dependent Cells
β Scribed by Chun-Chung Lee; Kou-Gi Shyu; Shankung Lin; Bao-Wei Wang; Ya-Chen Liu; Hang Chang
- Book ID
- 115589468
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 261 KB
- Volume
- 291
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Synthesis of plasminogen activator inhibitor type-1 (PAI-1), a major physiological modulator of plasmin generation, is regulated by growth factors and changes in cell shape. To evaluate the specific relationship between PAI-1 gene expression and cytoarchitecture, serum-free cultures of quiescent rat
## Abstract Plasminogen activator inhibitorβ1 (PAIβ1) binds to the somatomedin B (SMB) domain of vitronectin. It inhibits the adhesion of U937 cells to vitronectin by competing with the urokinase receptor (uPAR; CD87) on these cells for binding to the same domain. Although the inhibitor also blocks