✦ LIBER ✦

Cell adhesion in cancer

✍ Scribed by Jean Paul Thiery

Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 549 KB
Volume: 4
Category: Article
ISSN: 1631-0705
DOI: 10.1016/s1631-0705(03)00031-8

No coin nor oath required. For personal study only.

✦ Synopsis

Cell adhesion is a key physiological event tightly coupled to other major cellular processes coordinating morphogenesis and histogenesis. Cell-to-cell and cell-to-extracellular matrix adhesion regulates the social behavior of cells in developing embryos and in the adult. These two adhesion systems also play a critical role in pathogenesis. In vertebrates, more than 3% of genes are thought to encode adhesion molecules. The largest cell adhesion molecule superfamily is that related to N-CAM, the members of which characteristically contain immunoglobulin domains. Cadherins, which also possess Ig domains, constitute another important superfamily with different properties. Integrins are major receptors for many extracellular matrix components. This review describes the structure and function of these adhesion systems and their impact in cancer invasion and metastasis.

📜 SIMILAR VOLUMES

Cell adhesion receptors and cancer

✍ Zhongxiang Lin; Wenjun Zhang 📂 Article 📅 1999 🏛 Springer 🌐 English ⚖ 851 KB

Paxillin modulates squamous cancer cell

Paxillin modulates squamous cancer cell adhesion and is important in pressure-augmented adhesion

✍ William C. Conway; Jochem Van der Voort van Zyp; Vijayalakshmi Thamilselvan; Mar 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 281 KB

## Abstract Paxillin is an adapter protein regulating signaling and focal adhesion assembly that has been linked to malignant potential in many malignancies. Overexpression of paxillin has been noted in aggressive tumors. Integrin‐mediated binding through the focal adhesion complex is important in

E-cadherin mediated adhesion system in c

E-cadherin mediated adhesion system in cancer cells

✍ Hitoshi Shiozaki; Hiroshi Oka; Masatoshi Inoue; Shigeyuki Tamura; Morito Monden 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 982 KB

## BACKGROUND. Cadherins are the family of functionally related transmembrane glycoproteins responsible for the Ca"-dependent cellkell adhesion mechanism that is crucial for the mutual association of vertebrate cells. Because cell dissociation and acquisition of cell motility occur in cancer invas

Platelet adhesiveness and cancer cell st

Platelet adhesiveness and cancer cell stickiness

✍ E. Jacobi 📂 Article 📅 1975 🏛 Springer 🌐 English ⚖ 835 KB

Neural cell adhesion molecule and perine

Neural cell adhesion molecule and perineural invasion in gallbladder cancer

✍ Hitoshi Seki; Kenji Koyama; Jun-Ichi Tanaka; Yasuhiko Sato; Akiko Umezawa 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB

To clarify the role of neural cell adhesion molecule (NCAM) in perineural invasion, NCAM expression was studied by immunohistochemical staining in 26 cases with gallbladder cancer. In gallbladder cancer, the incidence of perineural invasion and that of positive NCAM expression was 42% and 3 1 %, res

The E-cadherin-mediated cell–cell adhesi

The E-cadherin-mediated cell–cell adhesion system in human cancers

✍ S. Tamura 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 199 KB 👁 1 views

The process of cancer invasion and metastasis comprises a complex series of sequential steps. The initial step is the dissociation of cancer cells from the primary tumour through the breakdown of the cell adhesion system which includes integrins, selectins, CD44 and the cadherin families of molecule