𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cell adhesion and matrix remodeling genes identified by co-expression analysis

✍ Scribed by Michael G. Walker; Wayne Volkmuth

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
83 KB
Volume
3
Category
Article
ISSN
1438-7506

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cell adhesion and matrix remodeling are elements in many diseases, ranging from atherosclerosis and fibrosis to metastatic cancer. However, many genes that participate in these processes have not yet been identified. To find such genes, we looked for previously uncharacterized genes that are co‐expressed with known cell adhesion and matrix remodeling genes. The known genes in this study included MMP2, TIMP3, BM‐40, chondroitin, connective tissue growth factor, fibromodulin, IGFBP5, laminin, MGP, myosin light chain kinase, several collagens, and other matrix and adhesion proteins. We found eight previously uncharacterized genes, here named MXRA1 through MXRA8, that were strongly co‐expressed with these known adhesion and matrix genes. Five of the MXRA genes have a significant similarity to uncharacterized cDNA sequences or predicted proteins listed in the Genbank database, but otherwise show distant or no sequence similarity to genes with known function. Subsequent to our entry of the MXRA gene sequences in the Genbank, three of the eight genes have been independently described by other researchers: MXRA2 is α‐parvin, a cell‐matrix adhesion protein, MXRA4 is a C1 complement component receptor involved in cell adhesion, and MXRA5 is adlican, an adhesion proteoglycan. The analysis described here provides further evidence for the role of these genes in adhesion and matrix remodeling.

📜 SIMILAR VOLUMES

Co-regulation of pituitary tumor cell ad
Co-regulation of pituitary tumor cell adhesion and prolactin gene expression by glucocorticoid
✍ Phillip R. Spangler; Beverly C. Delidow 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 245 KB 👁 2 views

Rat 235-1 pituitary tumor cells are lactotrophs producing high levels of prolactin (PRL). Dexamethasone (Dex, 100 nM) inhibits PRL gene expression in 235-1 cells by 50%, while simultaneously decreasing cell replication and cell-cell aggregation. To determine the time course of Dex action, we used a

Analysis of gene expression in cancer ce
Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis
✍ Edoardo Missiaglia; Ekaterini Blaveri; Benoit Terris; Yao-He Wang; Eithne Costel 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 906 KB

## Abstract Pancreatic cancer is a highly aggressive type of malignancy and the prognosis for disease presenting typically at a late stage is extremely poor. A comprehensive understanding of its molecular genetics is required in order to develop new approaches to clinical management. To date, seria

Lunasin induces apoptosis and modifies t
Lunasin induces apoptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells
✍ Vermont P. Dia; Elvira Gonzalez de Mejia 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 384 KB

## Abstract Scope: Lunasin is an arginine‐glycine‐aspartic acid (RGD) cancer preventive peptide. The objective was to evaluate the potential of lunasin to induce apoptosis in human colon cancer cells and their oxaliplatin‐resistant (OxR) variants, and its effect on the expression of human extracell

Molecular basis of basal cell carcinoma:
Molecular basis of basal cell carcinoma: Analysis of differential gene expression by differential display PCR and expression array
✍ Thomas Welss; Marina Papoutsaki; Günter Michel; Julia Reifenberger; Sergio Chime 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 257 KB

## Abstract Basal cell carcinoma (BCC) is the most common tumor in the Caucasian population. Although BCC rarely metastasize and cause death, they are problematic due to their destructive growth and the frequent localization on the face. Until now the knowledge of genes differentially expressed in