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Cefepime/daptomycin

✍ Scribed by Forbes, William; Igboekwu, Aloysius

Book ID: 121607380
Publisher: Adis International Limited (now part of Wolters Kluwer Health)
Year: 2013
Weight: 140 KB
Volume: 1477
Category: Article
ISSN: 0114-9954
DOI: 10.1007/s40278-013-7013-y

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## Abstract Synthesis of cefepime‐d~3~ (6a) and cefepime‐d~8~ (6b) is described. Diphenylmethyl 7‐benzylideneamino‐3‐chloromethyl‐3‐cephem‐4‐carboxylate (2) was treated with sodium iodide to afford the iodide 3, which was, without isolation, allowed to react with N‐methyl‐d~3~‐pyrrolidine to give t