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C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells

✍ Scribed by Allagnat, F; Fukaya, M; Nogueira, T C; Delaroche, D; Welsh, N; Marselli, L; Marchetti, P; Haefliger, J A; Eizirik, D L; Cardozo, A K


Book ID
120226780
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
749 KB
Volume
19
Category
Article
ISSN
1350-9047

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The transcription factors CCAAT/enhancer binding protein (C/EBP)-␤ and -␦ are key regulators for the expression of the acute phase genes in the liver, such as complement component C3 and antichymotrypsin. In the brain, these acute phase proteins are produced in response to pro-inflammatory cytokines