## Abstract Dimethylpyridines undergo deuterium‐hydrogen exchange when heated in deuterium oxide containing potassium carbonate at ring positions 2 and 6 when these positions are unsubstituted and at methyl groups located at ring positions 2,4, and 6 exclusively.
CE hydrogen deuterium exchange-MS in peptide analysis
✍ Scribed by Simon S. M. Lau; Nick M. Stainforth; David G. Watson; Graham G. Skellern; Stephen A. C Wren; Justice N. A. Tettey
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 392 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0173-0835
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## Abstract Deuterium‐labeled analogs of the topoisomerase inhibitor batracylin were prepared for metabolism studies to further its evaluation as an antitumor agent. Established syntheses of unlabeled batracylin were adapted for the preparation of deuterated batracylin that was trideuterated in the
Hydrogen/deuterium exchange reactions of protonated and sodium cationized peptide molecules have been studied in the gas phase with a MALDI / quadrupole ion trap mass spectrometer. Unit-mass selected precursor ions were allowed to react with deuterated ammonia introduced into the trap cell by a puls