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cDNA cloning of the rat O6-methylguanine-DNA-methyltransferase

✍ Scribed by Iwonna Rahden-Staron; Françoise Laval


Book ID
115764584
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
819 KB
Volume
177
Category
Article
ISSN
0006-291X

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Activity of 06-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkyIguanines in DNA by accepting the alkyl group at a cysteine moiety. Inactivation of MGMT is a feasible way to ove