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cDNA cloning of mouse VLA-3 α subunit

✍ Scribed by Ken-Ichi Takeuchi; Kazuya Hirano; Tsutomu Tsuji; Toshiaki Osawa; Tatsuro Irimura

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
703 KB
Volume
57
Category
Article
ISSN
0730-2312

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✦ Synopsis

cDNA clones for mouse VLA (very late antigen)-3 a subunit (013 integrin) were isolated and sequenced. The encoded mouse a3 integrin subunit was composed of 1,053 amino acid residues. The results of sequence analysis revealed similar structural characteristics to other VlA 01 subunits. For example, the presence of a large extracellular domain including three putative metal binding sequences, a transmembrane domain, and a short cytoplasmic domain. A higher level of its message was detected in thymus than in kidney, stomach, spleen, liver, brain, or lung by Northern blotting analysis. L 1995 WlIey-Liss, inc.

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