## Abstract Conventional osteosarcoma is characterized by rapid growth, high local aggressiveness, and metastasizing potential. Patients developing lung metastases experience poor prognosis despite extensive chemotherapy regimens and surgical interventions. Previously we identified a subgroup of os
CDKN2A Gene Deletions and Loss of p16 Expression Occur in Osteosarcomas That Lack RB Alterations
โ Scribed by Gunnlaugur P. Nielsen; Karen L. Burns; Andrew E. Rosenberg; David N. Louis
- Book ID
- 117022786
- Publisher
- American Society for Investigative Pathology
- Year
- 1998
- Tongue
- English
- Weight
- 703 KB
- Volume
- 153
- Category
- Article
- ISSN
- 0002-9440
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
To elucidate the possibility of the existence of multiple tumor suppressor genes on chromosome arm 9p, we performed genetic and epigenetic analyses of the CDKN2A/p16/MTS1 and CDKN2B/p15/MTS2 genes as well as homozygous deletion mapping of 9p in human lung carcinoma. To avoid overlooking genetic alte
Deletion of 9~21-22 is a common genetic alteration in dysplastic. in situ, and invasive head and neck squamous cell carcinoma (HNSCC). However, a candidate tumor suppressor gene (TSG) at this site has thus far not been identified in HNSCC. We report homozygous deletion of the recently identified mul