𝔖 Bobbio Scriptorium
✦   LIBER   ✦

CDKN2A common variant and multi-organ cancer risk—a population-based study

✍ Scribed by Tadeusz Dębniak; Rodney J. Scott; Tomasz Huzarski; Tomasz Byrski; Andrzej Rozmiarek; Boguslaw Dębniak; Bohdan Górski; Cezary Cybulski; Krzysztof Mędrek; Marek Mierzejewski; Bartłomiej Masojc; Joanna Matyjasik; Elzbieta Złowocka; Urszula Teodorczyk; Marcin Lener; Ewa Klujszo-Grabowska; Katarzyna Nej-Wołosiak; Ewa Jaworowska; Dorota Oszutowska; Anna Szymańska; Jolanta Szymańska; Jennifer Castaneda; Thierry van de Wetering; Janina Suchy; Grzegorz Kurzawski; Oleg Oszurek; Steven Narod; Jan Lubinski

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
65 KB
Volume
118
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The population frequencies of the CDKN2A common variants remain undetermined. In Poland, there is a common variant of the CDKN2A: an alanine to threonine substitution (A148T), which has been detected in other populations. We have recently showed that it is significantly overrepresented among Polish melanoma patients when compared to general population. Herein, we ascertained the prevalence of the A148T variant in 3,583 unselected cancer cases and 3,000 random control subjects from the same Polish population. We evaluated eleven different malignancies, representing the majority of all common cancer sites. Positive association with A148T variant was observed for lung cancer (OR, 2.0; p = 0.0052). A similar trend, although nonsignificant after the Bonferroni correction, was observed for colorectal cancer (OR, 1.5; p = 0.5499). These results suggest that A148T variant may be associated with a multi‐organ cancer risk in the Polish population. © 2006 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

MC1R common variants, CDKN2A and their a
MC1R common variants, CDKN2A and their association with melanoma and breast cancer risk
✍ Tadeusz Dȩbniak; Rodney Scott; Bartłomiej Masojc; Pablo Serrano-Fernández; Tomas 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 89 KB 👁 1 views

## Abstract We sought to examine the association between MC1R variants and the risk of melanoma and breast cancer in Polish population. We also determined the prevalence of compound heterozygous carriers of MC1R and CDKN2A (A148T) variants. We examined 500 unselected melanoma cases, 511 consecutive

Rare germline mutations in PALB2 and bre
Rare germline mutations in PALB2 and breast cancer risk: A population-based study
✍ Marc Tischkowitz; Marinela Capanu; Nelly Sabbaghian; Lili Li; Xiaolin Liang; Max 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 154 KB 👁 1 views

Germline mutations in the PALB2 gene are associated with an increased risk of developing breast cancer but little is known about the frequencies of rare variants in PALB2 and the nature of the variants that influence risk. We selected participants recruited to the Women's Environment, Cancer, and Ra

Coffee drinking and risk of endometrial
Coffee drinking and risk of endometrial cancer—A population-based cohort study
✍ Emilie Friberg; Nicola Orsini; Christos S. Mantzoros; Alicja Wolk 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 103 KB 👁 2 views

## Abstract Coffee drinking has been reported to have beneficial effects on insulin resistance, which has been directly associated with endometrial cancer. Although a relationship between coffee consumption and endometrial cancer risk is biologically plausible, this hypothesis has been previously e

Melanocortin receptor 1 variants and mel
Melanocortin receptor 1 variants and melanoma risk: A study of 2 European populations
✍ Dominique Scherer; Eduardo Nagore; Justo Lorenzo Bermejo; Adina Figl; Rafael Bot 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 223 KB 👁 1 views

## Abstract Variation within the __melanocortin receptor 1__ (__MC1R__) gene, that influences phenotypic traits and susceptibility to melanoma, is abundant across the populations. We assessed and compared the risk of melanoma in 2 European populations, German and Spanish, by genotyping __MC1R__ var

Flavonoid intake and ovarian cancer risk
Flavonoid intake and ovarian cancer risk in a population-based case-control study
✍ Margaret A. Gates; Allison F. Vitonis; Shelley S. Tworoger; Bernard Rosner; Lind 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 104 KB 👁 2 views

## Abstract Several recent studies have evaluated the association between dietary flavonoid intake and ovarian cancer risk, and all reported significant or suggestive inverse associations with certain flavonoids or flavonoid subclasses; however, most of these studies were small to moderate in size.

Re: Coffee drinking and risk of endometr
Re: Coffee drinking and risk of endometrial cancer—A population-based cohort study
✍ Marc J. Gunter 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 55 KB 👁 2 views

## Friberg et al. present data from a large cohort of Swedish females that demonstrate a significant, inverse association between coffee consumption and risk of endometrial cancer. 1 This finding corroborates the results from a recent prospective study conducted in Japan that also reported an inve