Germline mutations of the CDKN2A gene are found in melanoma-prone families and individuals with multiple sporadic melanomas. The encoded protein, p16(INK4A), comprises four ankyrin-type repeats, and the mutations, most of which are missense and occur throughout the entire coding region, can disrupt
CDKN2A and CDK4 mutation analysis in Italian melanoma-prone families: functional characterization of a novel CDKN2A germ line mutation
β Scribed by Torre, G Della; Pasini, B; Frigerio, S; Donghi, R; Rovini, D; Delia, D; Peters, G; Huot, T J G; Bianchi-Scarra, G; Lantieri, F
- Book ID
- 111724603
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 120 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0007-0920
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