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Cdk9, a member of the cdc2-like family of kinases, binds to gp130, the receptor of the IL-6 family of cytokines

✍ Scribed by Falco, Giulia De; Neri, Luca Maria; Falco, Maria De; Bellan, Cristiana; Yu, Zailin; Luca, Antonio De; Leoncini, Lorenzo; Giordano, Antonio

Book ID
110067104
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
230 KB
Volume
21
Category
Article
ISSN
0950-9232

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The cytokines IL-6, LIF, CNTF, OSM, IL-11, and CT-1 have been grouped into the family of IL-6-type cytokines, since they all require gp130 for signal transduction. Interestingly, gp130 binds directly to OSM, whereas complex formation with the other cytokines depends on additional receptor subunits.