CD95 Ligand expression enhances growth of murine renal cell carcinoma in vivo
โ Scribed by Hiroaki Nishimatsu; Takumi Takeuchi; Tetsuo Ueki; Takahiro Kajiwara; Nobuo Moriyama; Toshimitsu Ishida; Baoxing Li; Tadao Kakizoe; Tadaichi Kitamura
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 453 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0340-7004
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Laminin ฮณ2 chain is a subunit of the heterotrimeric basement membrane protein lamininโ332 (ฮฑ3ฮฒ3ฮณ2). The ฮณ2 chain is highly expressed by human cancers at the invasion fronts and this expression correlates with poor prognosis of the cancers. Our previous study showed that the ฮณ2 chain is
## Abstract Survivin, a novel member of the inhibitor of apoptosis protein (IAP) family, reduces the susceptibility of tumor cells to proapoptotic stimuli, thereby promoting tumor cell survival during tumor progression and treatment with anticancer drugs. Recently, we identified 2 novel alternative
## Angiogenesis is essential for the development of a solid tumor, including hepatocellular carcinoma (HCC). HCC is a well-known hypervascular tumor. Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic factors. Its role has not been clarified in vivo in HCC development.
CD95 (Apo-1/Fas) ligand (CD95L) expression has been observed in various malignancies. In human primary cell lines from a squamous cell carcinoma (SCC) of the vulva, the effect of cisplatin (CDDP) and IFNโฅ on the expression of CD95L and its 2 receptor isoforms, CD95 transmembrane (CD95tm) and CD95 so