CD8+T cells from a patient with colon carcinoma, specific for a mutant p21-Ras-derived peptide (GLY13→ASP), are cytotoxic towards a carcinoma cell line harbouring the same mutation

p21-ras-peptide-specific T-cell response

p21-ras-peptide-specific T-cell responses in a patient with colorectal cancer. CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation (13Gly → Asp)

✍ Beate Fossum; Tobias Gedde-Dahl III; Jarle Breivik; Jon Amund Eriksen; Anne Spur 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 979 KB

Peptides derived from mutated ras are immunogenic in mice and humans, and represent a group of specific tumor antigens that are potential targets for immunotherapy. T-cell responses against mutant p2I ras can be initiated in vitro by repeated stimulation of peripheral-blood mononuclear cells with mu