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CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequency

โœ Scribed by Timothy J. Powell; Deborah M. Brown; Joseph A. Hollenbaugh; Tina Charbonneau; Roslyn A. Kemp; Susan L. Swain; Richard W. Dutton


Book ID
116366205
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
788 KB
Volume
113
Category
Article
ISSN
1090-2341

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The mechanistic basis of memory T-cell development is poorly defined. Phenotypic markers that define precursors at effector stages have been characterized for acute systemic infections with high antigen load. We asked whether such markers can identify memory precursors from early effectors (d6) to l