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CD8+ T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation

✍ Scribed by Philippe Stock; Tilmann Kallinich; Omid Akbari; David Quarcoo; Kerstin Gerhold; Ulrich Wahn; Dale T. Umetsu; Eckard Hamelmann


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
429 KB
Volume
34
Category
Article
ISSN
0014-2980

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✍ Takahiko Sugihara; Naoko Okiyama; Mihoko Suzuki; Kuniko Kohyama; Yoh Matsumoto; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 160 KB 👁 3 views

## Abstract ## Objective To substantiate a pathogenic role of cytotoxic CD8 T cells in the development of a murine polymyositis model, C protein–induced myositis (CIM). ## Methods Beta~2~‐microglobulin–null mutant, perforin‐null mutant, and wild‐type (WT) C57BL/6 mice were immunized with skeleta