Definitive engagement of cytotoxic CD8 T
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Takahiko Sugihara; Naoko Okiyama; Mihoko Suzuki; Kuniko Kohyama; Yoh Matsumoto;
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Article
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2010
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John Wiley and Sons
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English
⚖ 160 KB
👁 3 views
## Abstract ## Objective To substantiate a pathogenic role of cytotoxic CD8 T cells in the development of a murine polymyositis model, C protein–induced myositis (CIM). ## Methods Beta~2~‐microglobulin–null mutant, perforin‐null mutant, and wild‐type (WT) C57BL/6 mice were immunized with skeleta