CD8+ T cells of reactive arthritis patients recognize a peptide from the 60 kDa heat shock protein of Yersinia
✍ Scribed by S. Ugrinovic; A. Mertz; J. Braun; J. Sieper
- Book ID
- 108408950
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 184 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0165-2478
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## Abstract A commonly held postulate regarding the etiology of rheumatoid arthritis (RA) is that of antigenic mimicry. Recent interest has focused on the mycobacterial 65‐kDa heat‐shock protein (hsp) as a putative causal agent. The 65‐kDa hsp has over 40% sequence homology with the human hsp 60, a
## DR3-restricted T cells from different HLA-DR3-positive individuals recognize the same peptide (amino acids 2-12) of the mycobacterial 65-kDa heat-shock protein* Studies in experimental animals have demonstrated that the T cell response to immunogenic proteins is limited to one or a few epitopes
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