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CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity

✍ Scribed by David Kägi; Birgit Ledermann; Kurt Bürki; Hans Hengartner; Rolf M. Zinkernagel


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
564 KB
Volume
24
Category
Article
ISSN
0014-2980

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✍ Karim Benihoud; Danielle Bonardelle; Pierre Bobé; Nicole Kiger 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 701 KB

Autoimmune-prone MRL/lpr mice, homozygous for the lpr mutation, exhibit defective apoptosis and develop generalized lymphoproliferation with the accumulation of a double-negative (DN: CD4- CD8-) T cell population. The capacity of lpr T lymphocytes to effectuate Fas- and perforin-mediated cytotoxicit