MRL/lpr CD4−CD8− and CD8+ T cells, respe
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Karim Benihoud; Danielle Bonardelle; Pierre Bobé; Nicole Kiger
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Article
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1997
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John Wiley and Sons
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English
⚖ 701 KB
Autoimmune-prone MRL/lpr mice, homozygous for the lpr mutation, exhibit defective apoptosis and develop generalized lymphoproliferation with the accumulation of a double-negative (DN: CD4- CD8-) T cell population. The capacity of lpr T lymphocytes to effectuate Fas- and perforin-mediated cytotoxicit