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CD8 is needed for development of cytotoxic T but not helper T cells

✍ Scribed by Fung-Leung, Wai-Ping; Schilham, Marco W.; Rahemtulla, Amin; Kündig, Thomas M.; Vollenweider, Maja; Potter, Julia; van Ewijk, Willem; Mak, Tak W.


Book ID
121428088
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
764 KB
Volume
65
Category
Article
ISSN
0092-8674

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## Abstract Notch1 proteins are involved in binary cell fate decisions. To determine the role of Notch1 in the differentiation of CD4^+^ Th1 versus Th2 cells, we have compared T helper polarization __in vitro__ in naive CD4^+^ T cells isolated from mice in which the N1 gene is specifically inactiva