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CD72-Deficient Mice Reveal Nonredundant Roles of CD72 in B Cell Development and Activation

โœ Scribed by Chin Pan; Nicole Baumgarth; Jane R Parnes


Book ID
117722553
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
391 KB
Volume
11
Category
Article
ISSN
1074-7613

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CD72-mediated B cell activation involves
โœ Chandrasekar Venkataraman; Pei-Jung Lu; Anne Mette Buhl; Ching-Shih Chen; John C ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 206 KB ๐Ÿ‘ 2 views

Occupancy of the B cell glycoprotein, CD72 results in syk-independent activation of phospholipase-C + and calcium mobilization. The cytoplasmic tail of CD72 does not contain an immunoreceptor tyrosine-based activation motif to directly transduce signals into the B lymphocyte. Hence, we investigated