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CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors

✍ Scribed by Janka Held-Feindt; Rolf Mentlein

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
276 KB
Volume
98
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

CD70 (CD27 ligand) has been implicated in proapoptotic signals mediated by its receptor CD27 in lymphocytes as well as in proliferative effects induced by reverse signaling in CD70‐positive hematopoetic tumor cells. We were able to show that CD70 is expressed at the mRNA and protein level in human meningioma cells, glioma cells from solid human gliomas as well as glioma cell lines and 1 ependynoma. The intensity of CD70 expression varies considerably between different samples from 1 tumor type. In the U343 glioma cell line, CD70 was preferentially localized in the cell processes. Thus, our studies identify CD70 as a new marker molecule in brain tumors that are of nonhematopoetic origin. © 2002 Wiley‐Liss, Inc.

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