CD69+ and HLA-DR+ activation antigens on peripheral blood lymphocyte populations in metastatic breast and ovarian cancer patients: Correlations with survival following active specific immunotherapy
✍ Scribed by Mary Beth Bowen Yacyshyn; Sibrand Poppema; Ann Berg; Grant D. Maclean; Mark A. Reddish; Alison Meikle; B. Michael Longenecker
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 639 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Lymphocyte activation markers CD69 and HLA-DR were studied in metastatic breast and ovarian cancer patients who received active specific immunotherapy (ASI) using cancer vaccines containing the synthetic tumor-associated antigen sialyl-Tn or the Thomsen-Friedenreich antigen conjugated to KLH plus DETOX adjuvant. Breast cancer patients who showed prolonged survival following AS1 had lower numbers of total CD69+ and CD4+CD69+ cells prior to AS1 compared to patients who died. However, following ASI, the surviving patients showed an increase in CD69+ and CD4+CD69+ cells and the deceased patients showed a decrease. A greater than 50% increase in the percentage of cells bearing the activation marker CD69 is associated with an increase in survival in both ovarian and breast cancer patients. In the surviving breast cancer patients there was a significant decrease in the percentage of non-6 lymphocyte HLA-DR+ (CDZO-HIA-DR+) cells following cyclophosphamide treatment. A strong positive correlation was found between lymphocyte populations CDZO-HLA-DR+ and CDB+CD57+, a putative suppressor cell population. Breast cancer patients who showed a greater than median decrease in CDZO-HLA-DR+ lymphocytes following cyclophosphamide treatment had a survival advantage over patients who had less than the median decrease in the percent CDZO-HLA-DR+ lymphocytes.