✦ LIBER ✦

CD5 positive immunoregulatory B cells in spleen populations from multiple myeloma patients

✍ Scribed by Dr. Malcolm R. MacKenzie; Teresa Paglieroni; Vincent Caggiano

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 332 KB
Volume: 37
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830370306

No coin nor oath required. For personal study only.

✦ Synopsis

CD19+CD5+ lymphocytes constitute a minority of peripheral blood B cells. In view of the importance of these cells in the pathogenesis of the immunoregulation of myeloma, their incidence in another lymphoid organ was determined. CD5+ B cells were studied in 9 spleens from patients with multiple myeloma and in 10 spleens from normal individuals removed secondary to trauma. The total number of CD19t B cells were increased in myeloma spleens (44.4% t 12.6%) as compared to normal spleens (20.4% 2 7.4%). Likewise, the percentage of CD19 cells which co-expressed CD5 were increased in myeloma (25.3% t 12.4%) versus normal (4.4% -r-2.3%) spleen. CD5+ B cells isolated from myeloma spleens, but not normal spleens, inhibit production of immunoglobulin in a pokeweed mitogen driven assay. Thus the spleen appears to be an important source of immunoregulatory B cells in multiple myeloma.

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