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CD5-Mediated Negative Regulation of Antigen Receptor-Induced Growth Signals in B-1 B Cells

✍ Scribed by Bikah, G.; Carey, J.; Ciallella, J. R.; Tarakhovsky, A.; Bondada, S.

Book ID
121157163
Publisher
American Association for the Advancement of Science
Year
1996
Tongue
English
Weight
430 KB
Volume
274
Category
Article
ISSN
0036-8075

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Negative regulation of antigen receptor-
Negative regulation of antigen receptor-mediated signaling by constitutive asociation of CD5 with the SHP-1 protein tyrosine phosphatase in B-1 B cells
✍ Goutam Sen; Gabriel Bikah; Chandrasekar Venkataraman; Subbarao Bondada πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 172 KB πŸ‘ 3 views

CD5, a membrane-associated glycoprotein, has been shown to negatively regulate antigen receptor-mediated growth responses in peritoneal B lymphocytes, thymocytes and mature T cells. The CD5-expressing peritoneal B cells (B-1) that are normally unresponsive to B cell receptor (BCR)-mediated growth si