Previous studies from our laboratory showed the development of circulating T lymphocytes sensitized to myelin basic protein (MBP) in guinea pigs challenged with MBP. Also, lymphocytes sensitized to MBP were found in patients with multiple sclerosis (MS). In this report, we describe the kinetics of M
β¦ LIBER β¦
CD4+CD25+FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis
β Scribed by Manoj Kumar; Norman Putzki; Volker Limmroth; Ralph Remus; Monika Lindemann; Dietmar Knop; Norbert Mueller; Cornelia Hardt; Ernst Kreuzfelder; Hans Grosse-Wilde
- Book ID
- 113729940
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 215 KB
- Volume
- 180
- Category
- Article
- ISSN
- 0165-5728
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## Abstract Accumulating evidence indicates an immunosuppressive role for CD4^+^CD25^+^ regulatory T cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with relapsingβremitting multiple sclerosis (RRβMS) has been reported recently, no information is available so fa