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CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

✍ Scribed by Edinger, Matthias; Hoffmann, Petra; Ermann, Joerg; Drago, Kathryn; Fathman, C Garrison; Strober, Samuel; Negrin, Robert S


Book ID
109933285
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
465 KB
Volume
9
Category
Article
ISSN
1078-8956

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Selective depletion of marrow-T cytotoxi
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In vitro depletion of mature pan-T lymphocytes has been widely and successfully used to prevent acute graft-versus-host disease (GVHD) after allogeneic bone-marrow transplantation (BMT). However, this procedure has been associated with a high incidence of graft failure and leukemic relapse. In this