Regulation of autoimmune diabetes by non
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Anish Suri; Jun Shimizu; Jonathan D. Katz; Shimon Sakaguchi; Emil R. Unanue; Osa
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Article
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2004
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John Wiley and Sons
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English
⚖ 145 KB
Diabetogenic BDC2.5 CD4 T cells induce diabetes when injected into NOD.scid mice. However, when co-transferred with the OVA-specific DO11.10 CD4 T cells, BDC2.5 T cells failed to cause diabetes. This inhibition depended upon the stimulation of DO11.10 T cells only with soluble OVA, which skewed thei