CD45 and the thymus
β Scribed by P.C.L. Beverley
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 134 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0165-2478
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## Human CD4+CD45RO+ and CD4+CD45RA+ T cells synergize in response to alloantigens\* Alloantigens, unlike recall antigens, activate both CD45RA+ (naive) and CD45RO+ (memory) CD4+ cells to the same extent. These Tcell subsets may therefore interact with each other in response to alloantigens on tra
CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta