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CD44 signaling through focal adhesion kinase and its anti-apoptotic effect

✍ Scribed by Yoshihisa Fujita; Motoo Kitagawa; Sukeyuki Nakamura; Kazuhiko Azuma; Genichiro Ishii; Morihiro Higashi; Hirohisa Kishi; Takaki Hiwasa; Keiji Koda; Nobuyuki Nakajima; Kenichi Harigaya

Book ID: 117104608
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 373 KB
Volume: 528
Category: Article
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(02)03262-3

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## Abstract Multicellular resistance (MCR) is produced because multicellular spheroids (MCSs) are formed with a broad cell–cell connection when cultured in three‐dimensions, which limits the clinical treatment efficacy in solid tumors. Focal adhesion kinase (FAK) plays an important role in apoptosi