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CD437 induces apoptosis in ovarian adenocarcinoma cells via ER stress signaling

โœ Scribed by Yumi Watanabe; Hiroyuki Tsuchiya; Tomohiko Sakabe; Saori Matsuoka; Yuji Akechi; Yuka Fujimoto; Keitaro Yamane; Remina Ikeda; Ren Nishio; Kei Terabayashi; Kyoko Ishii; Kazue Gonda; Yoshiaki Matsumi; An Afida Ashla; Hideharu Okamoto; Kazuko Takubo; Akiko Tomita; Yoshiko Hoshikawa; Akihiro Kurimasa; Hiroaki Itamochi; Tasuku Harada; Naoki Terakawa; Goshi Shiota

Book ID
116296117
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
359 KB
Volume
366
Category
Article
ISSN
0006-291X

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โœ Tianying Jiang; Dianne Robert Soprano; Kenneth J. Soprano ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 417 KB

## Abstract Ovarian cancer is one of the leading causes of cancer death in women. A number of studies have suggested that synthetic retinoids may play an important role as an ovarian cancer chemotherapeutic agent. The synthetic retinoid CD 437 induces apoptosis in ovarian tumor cells by a mechanism