CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid β-peptide

Differential regulation of BACE1 promote

Differential regulation of BACE1 promoter activity by nuclear factor-κB in neurons and glia upon exposure to β-amyloid peptides

✍ Krystyn Z. Bourne; Diana C. Ferrari; Christine Lange-Dohna; Steffen Roßner; Thom 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 484 KB

## Abstract The brains of Alzheimer's disease (AD) patients display cerebrovascular and parenchymal deposits of β‐amyloid (Aβ) peptides, which are derived by proteolytic processing by the β‐site APP‐cleaving enzyme 1 (BACE1) of the amyloid precursor protein (APP). The rat BACE1 promoter has a nucle