CD40-Mediated Apoptosis in Murine B-Lymphoma Lines Containing Mutated p53
โ Scribed by Annette C. Hollmann; Qiaoke Gong; Trevor Owens
- Book ID
- 115604390
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 336 KB
- Volume
- 280
- Category
- Article
- ISSN
- 0014-4827
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The role of bcl-xL in CD40-mediated rescue from anti-y-induced apoptosis in WEHI-231 B lymphoma cells The phenotypically immature B cell lymphoma WEHI-231 undergoes apoptotic cell death when cultured with anti-immunoglobulin (Ig) antibodies, via a bcl-Zindependent mechanism. We have therefore studi
## Abstract Diffuse large Bโcell lymphoma (DLBCL) is an aggressive malignancy with a variable response to therapy. We have previously shown that DLBCL cell lines differ in their susceptibility to CD40โmediated cell death, and that resistance to CD40โtargeted antibodies correlated with increased exp