CD40 expression in renal cell carcinoma correlates with tumor apoptosis, CD8 T cell frequency and patient survival
✍ Scribed by Jonathan M Weiss,Gregory Alvord,Octavio A Quinones…
- Book ID
- 126381359
- Publisher
- Springer (Biomed Central Ltd.)
- Year
- 2013
- Tongue
- English
- Weight
- 73 KB
- Volume
- 1
- Category
- Article
- ISSN
- 2051-1426
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## Abstract Many tumor cells are characterized by a dysregulated glucose metabolism associated with increased glycolysis in the presence of oxygen (“Warburg Effect”). Here, we analyzed for the first time a possible link between glucose metabolism and immune cell infiltration in renal cell carcinoma
CD40 is a cell surface receptor which, when ligated, modulates apoptosis in some cell types, perhaps via activation of the expression of members of the Bcl2 gene family. This study sought to determine whether expression of CD40 in a series of 134 squamous cell carcinomas (SCCs) of the lung was relat