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CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis

✍ Scribed by Shinji Shimoda; Hiroshi Miyakawa; Minoru Nakamura; Hiromi Ishibashi; Kentaro Kikuchi; Hiroto Kita; Hiroaki Niiro; Youjirou Arinobu; Nobuyuki Ono; Ian R. Mackay; M. Eric Gershwin; Koichi Akashi


Book ID
116614162
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
332 KB
Volume
31
Category
Article
ISSN
0896-8411

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Abnormal expression of PDC-E2 on the api
✍ Koichi Tsuneyama; Judy van de Water; David van Thiel; Ross Coppel; Boris Ruebner πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 945 KB

The presence of antimitochondrial antibodies (AMA) is a major criterion for the diagnosis of primary biliary cirrhosis (PBC). Although it is not clear that AMA are involved in the pathogenesis of the disease, the study of these autoantibodies has enabled much information to be accumulated about the