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CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons

✍ Scribed by Joseph Hesselgesser; Meredith Halks-Miller; Virginia DelVecchio; Stephen C. Peiper; James Hoxie; Dennis L. Kolson; Dennis Taub; Richard Horuk


Book ID
114320112
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
228 KB
Volume
7
Category
Article
ISSN
0960-9822

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## Abstract Within the brain, HIV‐1 targets the microglia and astrocytes. Previous studies have reported that viral entry into astrocytes is independent of CD4, in contrast to microglia. We aimed to determine whether chemokine receptors play a role in mediating CD4‐independent HIV‐1 entry into astr