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CD4+ immune escape and subsequent T-cell failure following chimpanzee immunization against hepatitis C virus

โœ Scribed by Montserrat Puig; Kathleen Mihalik; John C. Tilton; Ollie Williams; Michael Merchlinsky; Mark Connors; Stephen M. Feinstone; Marian E. Major


Book ID
102849464
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
614 KB
Volume
44
Category
Article
ISSN
0270-9139

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Selection-driven immune escape is not a
โœ Michael J. Fuller; Naglaa H. Shoukry; Toshifumi Gushima; David G. Bowen; Benoit ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 926 KB

Immune escape driven by selection pressure from virus-specific CD8 T cells has been demonstrated in both chimpanzees and humans infected with the hepatitis C virus (HCV). Although escape mutations have also been characterized in major histocompatibility complex (MHC) class II-restricted HCV epitopes