CD4+, HLA class I-restricted, cytolytic T-lymphocyte clone against primary malignant melanoma cells
β Scribed by Rajasekharan Somasundaram; Paul Robbins; Dilip Moonka; Elwyn Loh; Francesco Marincola; Amy Patel; DuPont Guerry; Dorothee Herlyn
- Book ID
- 101236195
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 93 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0020-7136
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π SIMILAR VOLUMES
## Abstract CD4^+^ Th cells that are restricted by MHC class II molecules play an important role in the induction of antitumor immune responses. We have established a stable CD4^+^ Th cell clone (Th35β1A) from the PBMCs of a patient with primary cutaneous melanoma. The Th cell clone is noncytolytic
Autologous mixed lymphocyte-tumor cell cultures (MLTC) were initiated with cytokine (IFNy and TNFa)-treated ex-vivo tumor cells of lung, ovarian, breast and stomach carcinomas. The cytokine-treated tumors expressed class-I but not class-ll molecules. Although the proportion of CD8+ lymphocytes incre