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CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis

✍ Scribed by M. Möttönen; J. Heikkinen; L. Mustonen; P. Isomäki; R. Luukkainen; O. Lassila


Book ID
108699096
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
214 KB
Volume
140
Category
Article
ISSN
0009-9104

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In the homeostasis of the immune system regulatory cells play a major role. Removal of one group of regulatory cells, the CD25(+)CD4(+) T cells, leads to autoimmune manifestations in experimental animal models, and reintroduction of this population prevents disease. This study addresses the role of