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CD4+ and CD8+ T lymphocytes: Clarification of their pathogenic roles in diabetes in the NOD mouse

✍ Scribed by T.W.H. Kay; H.L. Chaplin; J.L. Parker; L.A. Stephens; H.E. Thomas


Book ID
117614871
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
959 KB
Volume
148
Category
Article
ISSN
0923-2494

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While transgenic mice expressing tumour necrosis factor-alpha under the control of the betacell-specific insulin promoter display a marked lymphocytic infiltration of the islets, they never develop insulin-dependent diabetes mellitus (IDDM). In striking contrast, "double" transgenic mice whose beta