CD38 regulates oxytocin secretion and complex social behavior

✍ Scribed by Jennifer A. Bartz; L. Alison McInnes

• Book ID: 101710701
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 111 KB
• Volume: 29
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/bies.20623

✦ Synopsis

Abstract

The peptide hormone oxytocin plays a critical role in regulating affiliative behaviors including mating, pair‐bond formation, maternal/parenting behavior, social recognition, separation distress and other aspects of attachment. Jin and colleagues1 recently reported intriguing findings that CD38, a transmembrane receptor with ADP‐ribosyl cyclase activity, plays a critical role in maternal nurturing behavior and social recognition by regulating oxytocin secretion. This research may have implications for understanding disorders marked by deficits in social cognition and social functioning, including autism, social anxiety disorder, borderline personality disorder and schizophrenia. BioEssays 29:837–841, 2007. © 2007 Wiley Periodicals, Inc.