CD38 is expressed on human mature monocyte-derived dendritic cells and is functionally involved in CD83 expression and IL-12 induction

RIP2 mediates LPS-induced p38 and IκBα s

RIP2 mediates LPS-induced p38 and IκBα signaling including IL-12 p40 expression in human monocyte-derived dendritic cells

✍ Nurguel Usluoglu; Jovan Pavlovic; Karin Moelling; Gerald Radziwill 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB

## Abstract IL‐12, the critical factor for the generation of the Th1 type immune response, is produced by dendritic cells (DC) upon stimulation with LPS. Different signal pathways mediate LPS‐induced expression of IL‐12 and involve PI3K, MAPK and the transcription factor NF‐κB. Here, we show that t