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CD28 regulates glucocorticoid-induced TNF receptor family-related gene expression on CD4+ T cells via IL-2-dependent mechanisms

✍ Scribed by Adam P. Kohm; Joseph R. Podojil; Julie S. Williams; Jeffrey S. McMahon; Stephen D. Miller

Book ID: 113526867
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 671 KB
Volume: 235
Category: Article
ISSN: 0008-8749
DOI: 10.1016/j.cellimm.2005.07.002

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## Abstract The basis of the adjuvant effect of IL‐1 on the clonal expansion of Ag‐specific CD4 T cells was measured __in vivo__ using the TCR transgenic T cell adoptive transfer method. Injection ofAg plus IL‐1 caused naive CD4 T cells to proliferate to a greater extent than did injection of Ag al