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CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation

โœ Scribed by Masahiro Tsuchida; Eric R. Manthei; Stuart J. Knechtle; Majed M. Hamawy


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
92 KB
Volume
29
Category
Article
ISSN
0014-2980

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The adapter protein Shc has been implicated in mitogenic signaling via growth factor receptors, antigen receptors and cytokine receptors. Recent studies have suggested that tyrosine phosphorylation of Shc may play a key role in T lymphocyte proliferation via interaction of phosphorylated Shc with do